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Epidemiology and Genomics Research Program

Dana Wolff-Hughes, PhD

Program Director
Risk Factor Assessment Branch, Epidemiology and Genomics Research Program

Telephone: (240) 620-0673

  • PhD – Kinesiology
    University of Tennessee
  • MS – Exercise Physiology
    University of Tennessee
  • BS – Exercise Science
    Elon University
Contact for questions about:
  • Digital health technologies and platforms
  • Assessment and validation of digital biomarkers (including physical activity, sedentary behavior, and sleep)
  • Analytical methods and models
  • Computational models for multidimensional cancer risk factors


Dr. Dana Wolff-Hughes is a program director in the Risk Factor Assessment Branch (RFAB) of the Epidemiology and Genomics Research Program (EGRP) in NCI's Division of Cancer Control and Population Sciences (DCCPS). In this capacity, she supports work which validates and utilizes digital technology for cancer risk factor assessment (including physical activity, sedentary behavior, and sleep) in research and population surveillance.

She currently serves as the NIH coordinator and NCI scientific contact for the NSF-NIH Smart and Connected Health Initiative. Additionally, she is a scientific contact on Funding Opportunity Announcements (FOAs) and Notices of Special Interest (NOSIs) focused on digital health and data science such as the validation of digital health and AI technologies NOSI (NOT-CA-22-037).

Additionally, Dr. Wolff-Hughes represents NCI on several trans-NIH initiatives including the Researching COVID to Enhance Recovery (RECOVER) initiative and the All of Us Research program.

Dr. Wolff-Hughes’s scientific interests include novel methods and analytical approaches for risk factor assessment using digital technology, health information technology, and temporally linked contextual data. She is particularly interested in how the accuracy of physical activity measures influence dose response relationships, with a focus on methods to better interpret and understand data from digital technology.

Prior to joining EGRP, Dr. Wolff-Hughes was a health scientist administrator for the National Institutes of Health’s Office of Behavioral and Social Sciences Research (OBSSR). In this role, she coordinated trans-NIH initiatives focused on the application of innovative assessment, monitoring, and analytic approaches using digital and sensor technologies as well as health information technology to advance behavioral and social sciences research. She first joined NCI as a Cancer Research Training Award fellow in the Applied Research Program (now the Healthcare Delivery Research Program) and the Behavioral Research Program.

Select Publications

See listing of articles authored by Dr. Wolff-Hughes in PubMed.