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Purpose
The Think Tank on Quality Assurance and Quality Control in Untargeted Metabolomics Studies was the first step in developing a collaborative effort between important stakeholders in academia, industry and government institutions to address key quality assurance (QA) and quality control (QC) issues in the untargeted metabolomics field, that were in part identified through a survey administered by the Metabolomics Society Data Quality Task Group. The objectives of the Think Tank were to:
- Identify the most useful metrics for assessing study and data quality for untargeted metabolomic studies;
- Identify and prioritize both processes to ensure appropriate reporting of QA/QC data;
- Identify the types of test materials needed in the field of metabolomics for QA/QC in untargeted studies.
Related Research Consortium
The Metabolomics Quality Assurance and Quality Control Consortium (mQACC) was established following this 2017 Think Tank. mQACC is a collaborative effort among relevant stakeholders in academic, industry and government institutions to address key quality assurance (QA) and quality control (QC) issues in the untargeted metabolomics field. Learn about eligibility requirements to join mQACC.
Agenda
View agenda for Thursday, October 19, 2017
9609 Medical Center Dr., Rockville, MD 20850
| Time | Topic |
|---|---|
| 10:00 a.m. - 10:40 a.m. | Registration |
| 10:40 a.m. - 11:00 a.m. | Welcome and Attendee Introductions |
| Session 1: QA and QC in Untargeted Metabolomics | |
| 11:00 a.m. - 11:40 a.m. |
Meeting Introduction Quality control: an unbiased data cleaning protocol controlled by relative information content |
| 11:40 a.m. - 12:40 p.m. | Lunch |
| Session 2 | |
| 12:40 p.m. - 1:10 p.m. |
Taming the unknown: pragmatic approaches to quality control in untargeted metabolic phenotyping |
| 1:10 p.m. - 1:20 p.m. | Introduction to World Café |
| 1:25 p.m. - 1:40 p.m. | World Café*, Round 1 |
| 1:45 p.m. - 2:00 p.m. | World Café, Round 2 |
| 2:00 p.m. - 2:20 p.m. | Break |
| 2:20 p.m. - 2:50 p.m. | World Café, Report Out |
| Session 3 | |
| 2:50 p.m. - 3:20 p.m. |
Reporting standards for QA/QC in untargeted metabolomics |
| 3:25 p.m. - 3:40 p.m. | World Café, Round 1 |
| 3:45 p.m. - 4:00 p.m. | World Café, Round 2 |
| 4:00 p.m. - 4:20 p.m. | Break |
| 4:20 p.m. - 4:50 p.m. | World Café, Report Out |
| 4:50 p.m. - 5:00 p.m. | Wrap-up |
| 6:00 p.m. - 7:00 p.m. | Group Social at The Bench |
View agenda for Friday, October 20, 2017
9609 Medical Center Dr., Rockville, MD 20850
| Time | Topic |
|---|---|
| 9:00 a.m. - 9:10 a.m. | Registration |
| Session 4 | |
| 9:10 a.m. - 9:40 a.m. |
Test materials for untargeted metabolomics |
| 9:45 a.m. - 10:00 a.m. | World Café, Round 1 |
| 10:05 a.m. - 10:20 a.m. | World Café, Round 2 |
| 10:20 a.m. - 10:40 a.m. | Break |
| 10:40 a.m. - 11:10 a.m. | World Café, Report Out |
| Priority Setting | |
| 10:40 a.m. - 11:10 a.m. | Overview |
| 11:15 a.m. - 11:35 a.m. | Voting |
| 11:35 a.m. - 12:40 p.m. | Finalize Priorities, Facilitated |
| 12:40 p.m. - 1:35 p.m. | Lunch |
| 1:35 p.m. - 2:35 p.m. | Development of Action Plan |
| 2:35 p.m. - 2:45 p.m. | Wrap-up |
*World Café is a brainstorming session that is the first step in identifying priorities.
Think Tank Summary
Berger RD, Dunn WB, Bandukwala A, Bethan B, Broadhurst D, Clish CB, Dasari S, Derr L, Evans A, Fischer S, Flynn T, Hartung T, Herrington D, Higashi R, Hsu P-C, Jones C, Kachman M, Karuso H, Kruppa G, Lippa K, Maruvada P, Mosley J, Ntai I, O'Donovan C, Playdon M, Raftery D, Shaughnessy D, Souza A, Spaeder T, Salholz B, Tayyari F, Ubhi B, Verma M, Walk T, Wilson I, Witkin K, Bearden DW, Zanetti KA. Towards quality assurance and quality control in untargeted metabolomics studies. Metabolomics. 2019 Jan [Epub ahead of print]