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Sarah Kalia, Ph.D., S.M., Sc.M.
Program Director, Genomic Epidemiology Branch
sarah.kalia@nih.gov
Andrea Burnett-Hartman, Ph.D., M.P.H.
Program Director, Clinical and Translational Epidemiology Branch
andrea.burnett-hartman@nih.gov
Overview
There are more than 50 known inherited, also known as hereditary, cancer syndromes; however, appropriate testing for these syndromes remains vastly underused in cancer prevention and treatment. Many individuals who carry a gene variant associated with inherited cancer syndromes are unaware of their inherited susceptibility for cancer and may not follow recommended screening, preventative, or treatment approaches. By improving awareness, availability, and uptake of testing by individuals and families at high risk for cancer, significant improvements can be made in the prevention and early treatment of cancer in individuals with inherited cancer syndromes.
Research is ongoing to develop, test, and implement evidence-based strategies to identify those at risk for inherited cancer syndromes and implement appropriate clinical management. Studies are also investigating strategies to improve access to genetic counseling and testing, risk communication and clinical decision-making, and appropriate follow-up care for individuals with inherited cancer syndromes.
The ultimate goal is to develop and improve the implementation of effective cancer prevention, early detection, and treatment approaches for individuals with inherited cancer syndromes.
Funding Opportunities
The Epidemiology and Genomics Research Program (EGRP) encourages investigator-initiated grant applications on the topic of inherited cancer syndromes.
View other EGRP, NCI, and NIH funding opportunities
Related Research Resources
Related Public Resources
- Cancer Genetics Overview (PDQ®) – Health Professional Version
- Cancer Genetics Risk Assessment and Counseling (PDQ®) – Health Professional Version
- Genetic Testing for Cancer Risk
- Genetic Testing for Inherited Cancer Susceptibility Syndromes
- The Genetics of Cancer
- Risk Assessments and Resources for Clinical Practice